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Gene Expression defining boundaries in the brain at CS22

Here data from immunohistochemical experiments has been compared with the digitally painted CS22 model. When the sections are aligned it becomes evident that that the gene expression patterns define boundaries between different anatomical regions:

Black arrowhead - diencephalon/telencephalon boundary.

Black arrow - pallial/subpallial boundary.

White arrowhead - boundary between lateral and medial ganglionic eminences.

White arrow - boundary between the prethalamus (prosomere 3) and the hypothalamus.

 

 
Transverse view of the painted model
     
 
Sagittal view - section plane is indicated by the line

Please click on the image for a larger view. Clicking on the gene name links to the data spatially mapped to the model in the HuDSeN gene expression database.

The original sections scanned at high (X20 magnification) are also available. Please contact us for a username and password.